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Clinical features of amoxicillin overdosage may include allergic reactions and GI effects such as nausea, vomiting and diarrhea. Symptomatic treatment with attention to water/electrolyte balance is recommended.
Crystalluria, in some cases leading to renal failure, has been observed after amoxicillin overdosage in adults and children. Adequate fluid intake and diuresis should be maintained to reduce the risk of amoxicillin crystalluria.
Interstitial nephritis resulting in oliguric renal failure has also been reported in a small number of patients after overdose with amoxicillin.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of amoxicillin.
Amoxicillin may be removed from circulation by hemodialysis.
